A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle.
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چکیده
Selec tiVe Respiratory Stimulating Ac t ion of Doxapram Conipared to Pentylenetet razol. KE N N ET H HIRSCH AND S. C. WANG 1 Behavioral Activities and Cardiovascular Function : Effects of Hexamethonium on Cardiovascular Changes during Strong Sustained Static Work in Rhesus Monkeys. P. B. 1)Ews AND J. A. HERD 12 Modification of the Effects of Chlorpromazine on Behavior in the Chimpanzee. LARRY D. BYRD. 24 Behavior as a Stimulus: Joint Effects of d-Amphetamine and Pentobarbital. 1ARC N. BItANcH. 33 A Comparison of Psychotomimetic Drug Effects on Rat Brain Norepinephrine Metabolism. JON M. STOLK, JACK I). BARcHAS, MICHAEL GOLDSTEIN, WILuAM BOGGAN AND DANIEL X. FREEDMAN 42 Behavioral Effects of Separate and Combined Administration of Naloxone and d-Amphetamine. STEPHEN G. HOLTZMAN 51 ‘-Tetrahydrocannibinol and 1 1-Hydroxy’-tetrahydrocannibinol: Behavioral Effects and Tolerance I)evelopment. D. S. KOSERSKY, D. E. MCMILLAN AND L. S. HARRIS 61 Effect of Chronic Methadone Administration on Pregnant Rats arid Their Offspring. DORIS BUCHENAUER, MARILYN TURNBOW AND MARVIN A. PETERS 66 Alpha Adrenergic Blocking Agents: Antinociceptive Activity and Enhancement of Morphine-induced Analgesia. THEODORE J. CICERO, EDWARD R. MEYER AND BEN R. SMITHLOFF 72 Methadone Inhibition of 3H-5-Hydroxytryptamine Uptake by Synaptosomes. FRANK R. CI0FALO. 83 The Effect of Low Environmental Temperature on the Tranylcypromine-Meperidine Interaction in Mice. PETER K. GESSNER, CAROLYN C. CLARKE AND MICHAEL ADLER 90 Potential Neurotransmitters and Receptor Mechanisms Involved in the Central Control of Body Temperature in Golden Hamsters. THOMAS G. REIGLE AND HAROLD H. WOLF 97 The Importance of Neuronal Uptake of Amines for Amphetamine-Induced Release of 3H-Norepinephrine from Isolated Brain Tissue ALBERT J. Azz. IIo, RONALD J. ZIANCE AND CHARLES 0. RUTLEDGE 110 Effects of Adrenergic Agonists and Antagonists on Potassium Metabolism. RAYMOND H. LocKWOOD AND BERT K. B. LUM 119 The Role of the Autonomic Nervous System in the Responses of the Perfused Canine Paw to Prostaglandins B1 and B2. STANLEY GREENBERG, JAMES A. ENGELHRECHT AND WILLIAM R. WILSON 130 Effects of Locally Infused Serotonin on Canine Forelimb Weight and Segmental Vascular Resistances. GARY F. MERRILL, ROBERT I. KLINE, FRANCIS J. HADDY AND GEORGE J. GREGA.... 140 Effect of Coenzyme Qio on Experimental Hypertension in Rats and Dogs. T0sHIJI IGARASHI,
منابع مشابه
The Effect of Enzyme Inhibitors on the Resting Potential and on the Ion Distribution of the Sartorius Muscle of the Frog
Isolated frog sartorii were exposed for 30 minutes to HETP-an irreversible anti-cholinesterase, and were then soaked in Ringer's at 15 degrees C. for 16 hours. At the end of the period of soaking the mean resting potential of the muscle fibers was only 29 mv. The decrease in the resting potential of the HETP-treated muscles was accompanied by a loss of potassium and a gain in sodium by the musc...
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The contractile responses of isolated Rana ridibunda frog sartorius muscle contractions evoked by electrical field stimulation (EFS) were studied at three temperature conditions of 17, 22 and 27 degrees C. Temperature-dependent increase of muscle contractility was found. ATP (10-100 microM) concentration dependently inhibited the electrical field stimulation-evoked contractions of sartorius mus...
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1. The effects of 1 or 2­3 weeks of acclimation to 4 °C and 24 °C of overwintering grass frogs (Rana temporaria) on the synaptic delay and on the time constant of the decay phase (tau) of miniature end-plate currents (MEPCs) in the neuromuscular junction of sartorius muscle were studied. In order to equalize the possible effects of differential starvation, the animals were usually c...
متن کاملT H E Characterization and Localization of Frog Skin
Frog skin cholinesterase is largely of the serum (pseudocholinesterase) type. For whole skin, the activity at 10 --1 ~ AcChC1 is 4.9/~l./mg. N/hr. Tela subcutanea isolated by dissection exhibits an activity of 65 #l./mg. N/hr. at 10 --j ~ AcChC1. Since about one-tenth of the nitrogen of the skin is located in the tela subcutanea, it is estimated that more than 90 per cent of the enzyme is assoc...
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عنوان ژورنال:
- The Journal of pharmacology and experimental therapeutics
دوره 189 2 شماره
صفحات -
تاریخ انتشار 1974